Team

I received my BA in Chemistry and Physics from Harvard, followed by a Ph.D. in theoretical physics at MIT , where I studied protein folding, DNA biophysics, and the statistical mechanics of polymer gels with Toyoichi Tanaka, Alexander Grosberg, and Mehran Kardar. I moved into computational biology during my postdoc at UC San Francisco with Prof. Hao Li in the Biochemistry and Biophysics Department. There I trained in the molecular evolution of genomes and gene regulatory processes. I was a junior faculty in the Biology Department at Boston College then joined the Jackson Laboratory for Genomic Medicine. I am a Professor and the Donald A. Roux Chair for Genomics and Computational Biology at JAX-GM, with joint appointments in the UCONN-Health Department of Genetics and Genome Sciences and the University of Connecticut Department of Computer Science and Engineering. I have longtime interests in science communication, developed from my experience as a AAAS Mass Media Fellow, and I enjoy training students in both science and the communication skills that will help them share their work with others. I am Deputy Director of the JAX Cancer Center and a faculty advisor to the Data Analysis Core within JAX Data Sciences.

My research interests are in computational approaches for biological data analysis, especially: development of interpretable methods in deep learning-based tissue image analysis; comparative analysis of tissue imaging modalities such as H&E, CODEX, spatial transcriptomics, and multiplex FISH in cancer; cancer genomics and gene regulation; and the use of patient-derived cancer models to generate clinical trials. My lab’s research has been supported by organizations including the National Institutes of Health, the National Science Foundation, the Department of Defense, and the Hope Foundation.